Tandem Thiol Switch Synthesis of Peptide Thioesters via N–S Acyl Shift on Thiazolidine
2011; American Chemical Society; Volume: 13; Issue: 19 Linguagem: Inglês
10.1021/ol202047q
ISSN1523-7060
AutoresRohit K. Sharma, James P. Tam,
Tópico(s)Click Chemistry and Applications
ResumoAn efficient "thiol switch" approach for the synthesis of peptide thioesters via an acid-catalyzed N–S acyl shift and a thioester exchange reaction in tandem with concurrent removal of protecting groups is described. This method employs novel 2-(thiomethyl)thiazolidine (TMT)-anchored resins and is fully compatible with Fmoc chemistry.
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