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Zinc Triflate Catalyzed Aerobic Cross-Dehydrogenative Coupling (CDC) of Alkynes with Nitrones: A New Entry to Isoxazoles

2011; American Chemical Society; Volume: 13; Issue: 10 Linguagem: Inglês

10.1021/ol200849k

1523-7060

Sandip Murarka, Armido Studer,

Synthesis and Catalytic Reactions

A mild, operationally simple cross-dehydrogenative coupling between nitrones and terminal alkynes is described by using cheap, readily available 3,3′,5,5′-tetra-tert-butyldipheno-quinone and dioxygen as oxidants. These cross-couplings can be performed on various nitrones and alkynes with good to excellent yields. Product nitrones are readily transformed to pharmaceutically important 3,5-disubstituted isoxazoles.