DNA-Mediated Electron Transfer in DNA Duplexes Tethered to Gold Electrodes via Phosphorothioated dA Tags
2014; American Chemical Society; Volume: 30; Issue: 40 Linguagem: Inglês
10.1021/la502766g
ISSN1520-5827
AutoresRui Campos, Alexander Kotlyar, Elena E. Ferapontova,
Tópico(s)DNA and Nucleic Acid Chemistry
ResumoThe efficiency of DNA-based bioelectronic devices strongly depends on the way DNA molecules are linked to the electronic component. Commonly, DNA is tethered to metal electrodes via an alkanethiol linker representing an additional barrier for electron transport. Here we demonstrate that the replacement of the alkanethiol linker for a phosphorothioated adenosine tag increases the rate of DNA-mediated electron transfer (ET) up to 259 s(-1), representing the highest hitherto reported rate of electrochemically-modulated ET, and improves the stability of DNA-electrode surface binding. Both results offer pronounced technological and scientific benefits for DNA-based electronics.
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