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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Cytotoxic Cembranoids from the Red Sea Soft Coral Sarcophyton glaucum

2011; SAGE Publishing; Volume: 6; Issue: 12 Linguagem: Inglês

10.1177/1934578x1100601205

ISSN

1934-578X

Autores

Mohamed‐Elamir F. Hegazy, Ahmed A. El‐Beih, Alaa Y. Moustafa, Abdelhamed A. Hamdy, Montaser A. Alhammady, Rehab M. Selim, Mohamed Abdel‐Rehim, Paul W. Paré,

Tópico(s)

Microbial Natural Products and Biosynthesis

Resumo

One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7alpha,8beta-dihydroxydeepoxysarcophine (2), 7beta-acetoxy-8alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7beta-Acetoxy-8alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 microg/mL, respectively.

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