Teratogenic Compounds of Veratrum californicum (Durand) XI. Gestational Chronology and Compound Specificity in Rabbits
1971; SAGE Publishing; Volume: 136; Issue: 4 Linguagem: Inglês
10.3181/00379727-136-35453
ISSN1535-3702
Autores Tópico(s)Hedgehog Signaling Pathway Studies
ResumoSummaryFetal rabbits become malformed in ways grossly similar to lambs upon maternal ingestion of cyclopamine and jervine, naturally-occurring teratogens of Veratrum californicum. Other veratrum alkaloids tested were inactive. The cyclopia and related cephalic malformations occurred when ingestion took place on the 7th day of gestation.
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