Portal de Periódicos da CAPES

PAT-Enabled Determination of Design Space for Seeded Cooling Crystallization

2013; American Chemical Society; Volume: 17; Issue: 3 Linguagem: Inglês

10.1021/op300319t

1520-586X

Zai Qun Yu, Pui Shan Chow, Reginald B. H. Tan, Wei Han Ang,

Food Chemistry and Fat Analysis

A simple and practical procedure to facilitate the determination of the design space for seeded cooling crystallization is proposed and demonstrated. Solute supersaturation is used as an effective link between six operational process factors and a chosen critical quality attribute, namely, fines fraction in the crystal product. A semi-mechanistic process model is developed, which accounts for the dynamics of supersaturation via moments of particle size distribution. ATR-FTIR and FBRM data from three batches for the model system myo-inositol dihydrate in water were used to estimate and update the model parameters, and the design space was verified experimentally in a subsequent run.