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Acute intradialytic well-being: Results of a clinical trial comparing polysulfone with cuprophan

1991; Elsevier BV; Volume: 40; Issue: 4 Linguagem: Inglês

10.1038/ki.1991.265

1523-1755

G. Mingardi, Stefano Rota, Rocco Misiani, Stefanla Bernareggi, Ornella Facci, D. Marchesi, Arrigo Schieppati, Lucto Gualandris, Giancarlo Orlandini, Luca Reggiani Bonetti, Ariela Benigni, Antonella Piccinelli, Romana Licini, A. Mangili, G Mecca, Enza Poletti, Giacomo Tiraboschi, Claudio Grassi, O. Bracchi, G Pedroni, Agnese Meterange-Lis, Marco Lorenz, Patrizia Ondei, Luciano A. Pedrini, Giorgio Cozzi, Pietro Faranna, M Borghi, Giovanni Vendramin, M Massazza, Luciano Rusconi, P Giuliano,

Pharmacological Effects and Toxicity Studies

We conducted a multicenter, randomized, double-blind, controlled clinical trial to compare the effects of a synthetic, high-flux polysulfone membrane with a standard cuprophan one on acute clinical complications during a diffusive dialysis procedure. The principal end-point, that is, the number of hypotensive episodes, was similar in polysulfone (39; 23.8%) and cuprophan (32; 19.5%). Likewise, no significant difference was found between the two membranes as far as the secondary end-point was concerned, that is, the effect on headache, nausea, pruritus and sense of well-being. We conclude that high-flux polysulfone, acutely used in standard diffusive dialysis, has no favorable influence on hypotensive episodes and does not affect some typical dialysis-related symptoms any differently from cuprophan membrane. The need is stressed for well-controlled studies specifically designed to assess the worth of new dialysis techniques and materials that may vastly raise the cost of dialysis treatment.