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A14 Meningoencephalitis Following Rubella Vaccination

2012; Lippincott Williams & Wilkins; Volume: 29; Linguagem: Inglês

10.1097/01.eja.0000412460.13525.e6

1365-2346

Nader Baffoun, W. Dammak, M. Hamza, K. Baccar, N. Hammami, C. Drissi, I. Bounawas, C Kaddour,

Bacterial Infections and Vaccines

Introduction: Rubella vaccination in young women can be complicated by encephalitis (1/100 000 case) Case report: We report a case of meningoencephalitis following Rubella vaccination revealed by meningeal syndrome with fever, seizure and comatous state in a twenty-nine-year-old patient who had been vaccinated two weeks before. MRI find hypersignal T2 and FLAIR lesions on internal capsula pons evoking recent inflammatory lesions. Significant rate of IgM antibodies was found serum and in cerebrospinal liquid confirming inputability of vaccination. Outcome was favorable after intensive care admission including sedation and mechanical ventilation. Discussion: Neurological side effects may occur within 20 days post vaccination and are usually mild and temporary but serious complications such as meningoencephalitis have been also described. The pathogenesis of these disorders are discussed and supposed that there is a direct viral infection followed by an antigen-antibody reaction. This case illustrated by modern techniques of biology and imaging, completes the rare cases already described in the literature. References: T. Tsuru and al, Acute disseminated encephalomyelitis after live rubella vaccination Brain and Development Volume 22, Issue 4, 1 June 2000.