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Pyribenzamine Aerosol Inhalation and its Influence on Histamine Poisoning and Anaphylaxis

1947; SAGE Publishing; Volume: 64; Issue: 1 Linguagem: Inglês

10.3181/00379727-64-15710

1535-3702

Rudolf Mayer, David C. Brousseau, P. C. Eisman,

Phenothiazines and Benzothiazines Synthesis and Activities

1. PBZ inhaled in the form of an aerosol and in minute amounts, protects guinea pigs against histamine intoxication and anaphylactic shock. This protection is relatively long-lasting. 2. The selective protection which PBZ aerosols confer to the lung tissue permits the observation in guinea pigs of hitherto unrecorded histamine effects. 3. The high activity of PBZ aerosol inhalation and the apparent lack of irritation suggest the possible therapeutic use of PBZ as an aerosol, since it may be predicted that this method of administration produces a lasting therapeutic effect with doses too small to produce undesirable side reactions.