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Effect of Aerosolized Recombinant Human DNase on Exacerbations of Respiratory Symptoms and on Pulmonary Function in Patients with Cystic Fibrosis

1994; Massachusetts Medical Society; Volume: 331; Issue: 10 Linguagem: Inglês

10.1056/nejm199409083311003

1533-4406

Henry J. Fuchs, Drucy Borowitz, David Høyrup Christiansen, Edward M. Morris, Martha L. Nash, Bonnie W. Ramsey, Beryl J. Rosenstein, Arnold L. Smith, Mary Ellen B. Wohl,

Pharmaceutical studies and practices

Respiratory disease in patients with cystic fibrosis is characterized by airway obstruction caused by the accumulation of thick, purulent secretions, which results in recurrent, symptomatic exacerbations. The viscoelasticity of the secretions can be reduced in vitro by recombinant human deoxyribonuclease I (rhDNase), a bioengineered copy of the human enzyme.