Syntheses of (±)-Serratine, (±)-Lycoposerramine T, and (±)-Lycopoclavamine B
2013; American Chemical Society; Volume: 15; Issue: 9 Linguagem: Inglês
10.1021/ol400628h
ISSN1523-7060
AutoresHisaaki Zaimoku, H Nishide, Asami Nishibata, Naoya Goto, Tsuyoshi Taniguchi, Hiroyuki Ishibashi,
Tópico(s)Phytochemical compounds biological activities
ResumoThe first total syntheses of (±)-serratine, (±)-lycoposerramine T, and (±)-lycopoclavamine B have been accomplished. The functionalized octahydroindane skeleton of these natural products was constructed by an efficient Diels–Alder reaction of an α-alkynylcyclopentenone and the stereoselective introduction of a tertiary hydroxyl group. Two of these natural products were divergently synthesized from the same synthetic intermediate at a later stage.
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