Kadcoccitones A and B, Two New 6/6/5/5-Fused Tetracyclic Triterpenoids from Kadsura coccinea
2012; American Chemical Society; Volume: 14; Issue: 24 Linguagem: Inglês
10.1021/ol303168y
ISSN1523-7060
AutoresCheng-Qin Liang, Yi‐Ming Shi, Rong‐Hua Luo, Xing-Yao Li, Zhong‐Hua Gao, Xiao‐Nian Li, Liu‐Meng Yang, Shan‐Zhai Shang, Yan Li, Yong‐Tang Zheng, Hongbin Zhang, Wei‐Lie Xiao, Han‐Dong Sun,
Tópico(s)Alkaloids: synthesis and pharmacology
ResumoA pair of new triterpenoid epimers, kadcoccitones A (1) and B (2), together with a new biogenetically related compound kadcoccitone C (3), were isolated from Kadsura coccinea. The epimers featured an unprecedented carbon skeleton with a 6/6/5/5-fused tetracyclic ring system unit and a C9 side chain. Their structures were determined by spectroscopic data, ECD calculation, and single-crystal X-ray diffraction. Compounds 1 and 3 showed anti-HIV-1 activity with an EC50 value of 47.91 and 32.66 μg/mL, respectively.
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