Artigo Revisado por pares

346 DO ASIAN AND CAUCASIAN MEN DEVELOP HIGH GRADE (GLEASON &[GE]7) PROSTATE CANCER AT THE SAME AGE? AN AUTOPSY STUDY

2013; Lippincott Williams & Wilkins; Volume: 189; Issue: 4S Linguagem: Inglês

10.1016/j.juro.2013.02.1732

ISSN

1527-3792

Autores

Alexandre R. Zlotta, Shinichi Egawa, Dmitry Pushkar, Alexander Govorov, Takahiro Kimura, Masahito Kido, Hiroyuki Takahashi, Cynthia Kuk, М. В. Ковылина, Najla Aldaoud, Neil Fleshner, Antonio Finelli, Laurence Klotz, Jenna Sykes, Gina Lockwood, Theodorus van der Kwast,

Tópico(s)

Urological Disorders and Treatments

Resumo

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History (II)1 Apr 2013346 DO ASIAN AND CAUCASIAN MEN DEVELOP HIGH GRADE (GLEASON &[GE]7) PROSTATE CANCER AT THE SAME AGE? AN AUTOPSY STUDY Alexandre R Zlotta, Shin Egawa, Dmitry Pushkar, Alexander Govorov, Takahiro Kimura, Masahito Kido, Hiroyuki Takahashi, Cynthia Kuk, Marta Kovylina, Najla Aldaoud, Neil E Fleshner, Antonio Finelli, Laurence Klotz, Jenna Sykes, Gina Lockwood, and Theodorus H van der Kwast Alexandre R ZlottaAlexandre R Zlotta Toronto, Canada More articles by this author , Shin EgawaShin Egawa Tokyo, Japan More articles by this author , Dmitry PushkarDmitry Pushkar Moscow, Russian Federation More articles by this author , Alexander GovorovAlexander Govorov Moscow, Russian Federation More articles by this author , Takahiro KimuraTakahiro Kimura Tokyo, Japan More articles by this author , Masahito KidoMasahito Kido Tokyo, Japan More articles by this author , Hiroyuki TakahashiHiroyuki Takahashi Tokyo, Japan More articles by this author , Cynthia KukCynthia Kuk Toronto, Canada More articles by this author , Marta KovylinaMarta Kovylina Moscow, Russian Federation More articles by this author , Najla AldaoudNajla Aldaoud Toronto, Canada More articles by this author , Neil E FleshnerNeil E Fleshner Toronto, Canada More articles by this author , Antonio FinelliAntonio Finelli Toronto, Canada More articles by this author , Laurence KlotzLaurence Klotz Toronto, Canada More articles by this author , Jenna SykesJenna Sykes Toronto, Canada More articles by this author , Gina LockwoodGina Lockwood Toronto, Canada More articles by this author , and Theodorus H van der KwastTheodorus H van der Kwast Toronto, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.1732AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES We have previously demonstrated that PCa prevalence is similar between Russian Caucasians and Japanese Asian men. We had chosen a specific Caucasian population in Russia with low penetrance of PSA screening. Autopsy data in North America and Western Europe would have been heavily contaminated due to opportunistic PSA screening. Screening in Japan is also uncommon. Here our aim was to compare the prevalence of Gleason ≥7 PCa on autopsy in Caucasian and Asian men. METHODS 320 prostate glands were prospectively collected during autopsy from men who died from causes other than PCa in Moscow (Russia n=220)-(CAU) and Tokyo (Japan n=100)-(ASI). The same harvesting methodology was followed in both sites. Prostates were removed en-block with the seminal vesicles within 24 hours of death and analyzed in toto (perpendicular sections at 4 mm intervals) by an experienced uro-pathologist. We compared across the ASI and CAU populations, the prevalence of GS≥7 PCa over the various age groups. RESULTS Overall, 37 out of 117 tumors (31.6%) were GS≥7, with a significantly higher proportion in ASI men (51.4%) compared to CAU men (23.2%, p=0.003). Fig 1 illustrates the prevalence of GS≥7 PCa in ASI and CAU men according to age. Compared to CAU, in our autopsy cohort, a higher prevalence of GS≥7 PCa was observed at a later age among ASI with a steeper increase in prevalence by the decade. Breaking down GS7 into (3+4) or (4+3), among 14 GS7 in ASI, 13 were 3+4 and 1 was 4+3. Among 16 CAU with GS7, 10 and 6 were 3+4 and 4+3, respectively, (p=0.086). Limitations include small population size and the absence of Caucasian men aged 80+. CONCLUSIONS A higher proportion of autopsy detected PCa in Asian men is GS≥7 compared to Caucasians. Asian men seem to have a higher prevalence of GS≥7 PCa at a later decade in life compared to Caucasian men. A hypothesis is that in Asian men, the grade progression is much faster than in Caucasian men. The alternative hypothesis would be a de novo origin of GS≥7 instead of grade progression. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e140 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alexandre R Zlotta Toronto, Canada More articles by this author Shin Egawa Tokyo, Japan More articles by this author Dmitry Pushkar Moscow, Russian Federation More articles by this author Alexander Govorov Moscow, Russian Federation More articles by this author Takahiro Kimura Tokyo, Japan More articles by this author Masahito Kido Tokyo, Japan More articles by this author Hiroyuki Takahashi Tokyo, Japan More articles by this author Cynthia Kuk Toronto, Canada More articles by this author Marta Kovylina Moscow, Russian Federation More articles by this author Najla Aldaoud Toronto, Canada More articles by this author Neil E Fleshner Toronto, Canada More articles by this author Antonio Finelli Toronto, Canada More articles by this author Laurence Klotz Toronto, Canada More articles by this author Jenna Sykes Toronto, Canada More articles by this author Gina Lockwood Toronto, Canada More articles by this author Theodorus H van der Kwast Toronto, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

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