Portal de Periódicos da CAPES

Fetal Surgery of Extremity Amniotic Bands

2009; Lippincott Williams & Wilkins; Volume: 29; Issue: 1 Linguagem: Inglês

10.1097/bpo.0b013e318192196e

1539-2570

Francisco Soldado, M Aguirre, José L. Peiró, César G. Fontecha, Marielle Esteves, Roberto Vélez, Vicenç Martínez-Ibáñez,

Congenital Diaphragmatic Hernia Studies

Extremity amniotic band (EAB) syndrome can cause an intrauterine amputation as a result of a mechanical effect with progressive strangulation. The aim of the study is to assess the use of fetal surgery of EABs with risk of amputation in the ovine fetus.Right limbs of fifteen 60-day-gestational age fetal sheep were ligated with silk suture at the infracondylar level. Left limbs were used for paired comparison. Fetuses were randomized into 3 groups: an early-repair group (n = 5), a late-repair group (n = 5), and a nonrepaired group (n = 5). The limbs of the 2 repaired groups underwent fetal release. The limbs obtained from at-term fetuses were analyzed morphologically, functionally, and radiologically. Statistical analysis with paired test was used to compare data.Nonrepaired limbs showed amputation or quasi amputation; the repaired ones did not. However, those late-repaired had significantly reduced passive ankle range of motion, shorter limb length, and mild residual changes.Intrauterine release of potentially severe EABs prevents limb amputation and leads to morphofunctional recovery. Early release shows better results.: Intrauterine amputations caused by EABs in the human fetus might be avoidable by fetal surgery.