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BIBTEX RIS

Lactimidomycin, a new glutarimide group antibiotic. Production, isolation, structure and biological activity.

1992; Springer Nature; Volume: 45; Issue: 9 Linguagem: Inglês

10.7164/antibiotics.45.1433

ISSN

1881-1469

Autores

Koko Sugawara, Yuji Nishiyama, SOICHIRO TODA, NOBUJIRO KOMIYAMA, Masami Hatori, TOSHIO MORIYAMA, YOSUKE SAWADA, Hideo Kamei, MASATAKA KONISHI, TOSHIKAZU OKI,

Tópico(s)

Bioactive Compounds and Antitumor Agents

Resumo

Streptomyces amphibiosporus R310-104 (ATCC 53964) produced a novel antibiotic lactimidomycin which showed inhibitory activity against fungi and prolonged the survival time of mice transplanted with experimental tumors. Structural studies clarified that lactimidomycin is a new glutarimide antibiotic having a unique unsaturated 12-membered lactone ring.

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