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Copper-Catalyzed Aerobic C(sp 2 )–H Functionalization for C–N Bond Formation: Synthesis of Pyrazoles and Indazoles

2013; American Chemical Society; Volume: 78; Issue: 8 Linguagem: Inglês

10.1021/jo400162d

1520-6904

Xianwei Li, He Li, Huoji Chen, Wanqing Wu, Huanfeng Jiang,

Sulfur-Based Synthesis Techniques

A simple, practical, and highly efficient synthesis of pyrazoles and indazoles via copper-catalyzed direct aerobic oxidative C(sp(2))-H amination has been reported herein. This process tolerated a variety of functional groups under mild conditions. Further diversification of pyrazoles was also investigated, which provided its potential for drug discovery.