Functional Gold Nanoparticles as Potent Antimicrobial Agents against Multi-Drug-Resistant Bacteria
2014; American Chemical Society; Volume: 8; Issue: 10 Linguagem: Inglês
10.1021/nn5042625
ISSN1936-086X
AutoresXiaoning Li, Sandra Robinson, Akash Gupta, Krishnendu Saha, Ziwen Jiang, Daniel F. Moyano, A Zaki Sahar, Margaret A. Riley, Vincent M. Rotello,
Tópico(s)Quantum Dots Synthesis And Properties
ResumoWe present the use of functionalized gold nanoparticles (AuNPs) to combat multi-drug-resistant pathogenic bacteria. Tuning of the functional groups on the nanoparticle surface provided gold nanoparticles that were effective against both Gram-negative and Gram-positive uropathogens, including multi-drug-resistant pathogens. These AuNPs exhibited low toxicity to mammalian cells, and bacterial resistance was not observed after 20 generations. A strong structure–activity relationship was observed as a function of AuNP functionality, providing guidance to activity prediction and rational design of effective antimicrobial nanoparticles.
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