Portal de Periódicos da CAPES

High-Dose Baclofen for Treatment-Resistant Alcohol Dependence

2012; Lippincott Williams & Wilkins; Volume: 32; Issue: 2 Linguagem: Inglês

10.1097/jcp.0b013e31824929b2

1533-712X

Adam Pastor, David Martyn Lloyd Jones, J. C. M. Currie,

Pain Mechanisms and Treatments

Alcohol dependence is associated with a wide array of physical and psychiatric complications and is a major cause of morbidity and mortality worldwide. Recent randomized trials of baclofen, with a total daily dose 30 mg administered in 3 divided doses, have supported its efficacy in reducing craving and promoting abstinence from alcohol. Individual case studies support a possible increased effect at higher doses for treatment-resistant patients. Here, we report on 4 alcohol-dependent patients resistant to standard treatments who responded to higher doses of baclofen ranging from 75 to 125 mg daily. Further research into the use of high-dose baclofen for treatment-resistant alcohol dependence is warranted.