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Inhibition of Development of Dictyocaulus filaria as an Expression of Immunity Attained in Sheep

1963; American Society of Parasitologists; Volume: 49; Issue: 4 Linguagem: Inglês

10.2307/3275768

1937-2345

A. Sokolić, Miloš Jovanović, K. Ćuperlović, M. Movsesijan,

Helminth infection and control

A high degree of immunity (81.8%) against thread lung worm, Dictyocaulus filaria, in sheep was obtained by double vaccination. The antigen of this vaccine, infective larvae, was attenuated at a level of 40,000 r, X rays of roentgen origin or gamma rays of Co'. Immunity was indicated by noticeable differences in: (a) the average number of larvae/g of feces/reproductive female recovered within the entire postchallenge period (0.07 : 1.40); (b) the number of parasites (24.1 : 168.8); (c) the relative mortality ( 0: 12.5% ); (d) the degree of clinical and pathomorphological changes, and (e) the degree of inhibition of parasitic development in general, but of oogenesis especially, comparing vaccinated immune animals with nonvaccinated controls. Studies of the possibility of immunizing a host against some species of parasites have great scientific and practical significance. Successful immunization against parasitic diseases could be a suitable method for their prevention, and in certain cases, could lead to their