Erythropoietin: structure, control of production, and function
1992; American Physiological Society; Volume: 72; Issue: 2 Linguagem: Inglês
10.1152/physrev.1992.72.2.449
ISSN1522-1210
Autores Tópico(s)PARP inhibition in cancer therapy
ResumoarticleErythropoietin: structure, control of production, and functionW. JelkmannW. JelkmannPhysiologisches Institut I, Universitat Bonn, Federal Republic ofGermany.Published Online:01 Apr 1992https://doi.org/10.1152/physrev.1992.72.2.449MoreSectionsPDF (12 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByShort exposure to intermittent hypoxia increases erythropoietin levels in healthy individualsFrank Wojan, Sten Stray-Gundersen, Mercedes J. 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Eltzschig, and Hartmut Osswald1 November 2007 | American Journal of Physiology-Renal Physiology, Vol. 293, No. 5Administration of poly-d-glutamic acid induces proliferation of erythropoietin-producing peritubular cells in rat kidneyBellamkonda K. Kishore, Jorge Isaac, and Christof Westenfelder1 February 2007 | American Journal of Physiology-Renal Physiology, Vol. 292, No. 2Erythropoietin and the cardiorenal syndrome: cellular mechanisms on the cardiorenal connectorsKim E. Jie, Marianne C. Verhaar, Maarten-Jan M. Cramer, Karien van der Putten, Carlo A. J. M. Gaillard, Pieter A. Doevendans, Hein A. Koomans, Jaap A. Joles, and Branko Braam1 November 2006 | American Journal of Physiology-Renal Physiology, Vol. 291, No. 5Increased serum erythropoietin but not red cell production after 4 wk of intermittent hypobaric hypoxia (4,000–5,500 m)Christopher J. Gore, Ferran A. Rodríguez, Martin J. Truijens, Nathan E. Townsend, James Stray-Gundersen, and Benjamin D. Levine1 November 2006 | Journal of Applied Physiology, Vol. 101, No. 5Endurance exercise differentially stimulates heart and axial muscle development in zebrafish (Danio rerio)T. van der Meulen, H. Schipper, J. G. M. van den Boogaart, M. O. Huising, S. Kranenbarg, and J. L. van Leeuwen1 October 2006 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 291, No. 4Mechanisms and Significance of EryptosisAntioxidants & Redox Signaling, Vol. 8, No. 7-8Role of Nitric Oxide in Cardiovascular Adaptation to Intermittent Hypoxia29 November 2016 | Experimental Biology and Medicine, Vol. 231, No. 4Evaluation of Epoetin Alpha (rHuEPO) and Darbepoetin Alpha (DARB) on Human Burst-colony Formation (BFU-E) in Culture25 June 2016 | Journal of International Medical Research, Vol. 34, No. 1Myocardial perfusion reserve in adults with cyanotic congenital heart diseaseRichard C. Brunken, Joseph K. Perloff, Johannes Czernin, Roxana Campisi, Susan Purcell, Pamela D. Miner, John S. Child, and Heinrich R. Schelbert1 November 2005 | American Journal of Physiology-Heart and Circulatory Physiology, Vol. 289, No. 5Is the renal production of erythropoietin controlled by the brain stem?Ursula von Wussow, Janina Klaus, and Horst Pagel1 July 2005 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 289, No. 1Roles of Brahma and Brahma/SWI2-Related Gene 1 in Hypoxic Induction of the Erythropoietin GeneJournal of Biological Chemistry, Vol. 279, No. 45THE SIGNIFICANCE OF SERUM ERYTHROPOIETIN LEVELS IN ASSESSING THE SEVERITY OF RENAL DAMAGE IN CHILDREN WITH REFLUX NEPHROPATHYThe Journal of Urology, Vol. 172, No. 4Thyroid hormone induces erythropoietin gene expression through augmented accumulation of hypoxia-inducible factor-1Yaluan Ma, Patricia Freitag, Jie Zhou, Bernhard Brüne, Stilla Frede, and Joachim Fandrey1 September 2004 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 287, No. 3Hypoxia-induced erythropoietin expression in human neuroblastoma requires a methylation free HIF-1 binding site29 June 2004 | Journal of Cellular Biochemistry, Vol. 93, No. 1Hypoxia–ischemia affects erythropoietin and erythropoietin receptor expression pattern in the neonatal rat brainBrain Research, Vol. 1021, No. 2Pretreatment with EPO reduces the injury and dysfunction caused by ischemia/reperfusion in the mouse kidney in vivoKidney International, Vol. 66, No. 3Pharmacokinetic and Pharmacodynamic Modeling of Recombinant Human Erythropoietin After Single and Multiple Doses in Healthy Volunteers8 March 2013 | The Journal of Clinical Pharmacology, Vol. 44, No. 9Erythropoietin prevents hypoxia/ischemia-induced DNA fragmentation in an experimental model of perinatal asphyxiaNeuroscience Letters, Vol. 366, No. 1Erythropoietin increases platelet reactivity and platelet counts in patients with alcoholic liver cirrhosis: a randomized, double-blind, placebo-controlled studyAlimentary Pharmacology and Therapeutics, Vol. 20, No. 4Oxygen-dependent and tissue-specific regulation of erythropoietin gene expressionJoachim Fandrey1 June 2004 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 286, No. 6The Use of Recombinant Human Erythropoeitin Stimulating Factor in Plastic Surgery3 August 2004 | Aesthetic Plastic Surgery, Vol. 28, No. 3Is there a place for epoetin alfa in managing anemia during critical illness?Clinical Therapeutics, Vol. 26, No. 6Antioxidant intervention does not affect the response of plasma erythropoietin to short-term normobaric hypoxia in humansA. M. Niess, E. Fehrenbach, I. Lorenz, A. Müller, H. Northoff, H.-H. Dickhuth, and E. M. Schneider1 March 2004 | Journal of Applied Physiology, Vol. 96, No. 3Erythropoietin and the nervous systemBrain Research, Vol. 1000, No. 1-2Detection of erythropoietin in human seminal plasmaFertility and Sterility, Vol. 81Blockade of erythropoietin signal at the early postimplantation period inhibits the development of decidua and embryo in miceCongenital Anomalies, Vol. 44, No. 1Performance characteristics of the IMMULITE 2000 erythropoietin assayClinica Chimica Acta, Vol. 340, No. 1-2Managing Anemia in the Critically Ill PatientPharmacotherapy, Vol. 24, No. 2Oxygen and the CellBiological Chemistry, Vol. 385, No. 3-4Effect of erythropoietin on Leydig cell is associated with the activation of Stat5 pathwayMolecular and Cellular Endocrinology, Vol. 213, No. 2Effect of erythropoietin on nitric oxide production in the rat hippocampus using in vivo brain microdialysisNeuroscience, Vol. 128, No. 1Red blood cell physiology in critical illnessCritical Care Medicine, Vol. 31, No. SupplementOxygen-regulated Expression of TGF-β3, a Growth Factor Involved in Trophoblast DifferentiationPlacenta, Vol. 24, No. 10Erythropoietin exerts neuroprotective effect in neonatal rat model of hypoxic–ischemic brain injuryBrain and Development, Vol. 25, No. 7Plasma angiopoietin-1, angiopoietin-2 and Tie-2 in breast and prostate cancer: a comparison with VEGF and Flt-1European Journal of Clinical Investigation, Vol. 33, No. 10Erythropoietin as an angiogenic factorEuropean Journal of Clinical Investigation, Vol. 33, No. 10Plasma erythropoietin level in patients with cirrhosis and its relationship to the severity of cirrhosis and renal functionJournal of Gastroenterology and Hepatology, Vol. 18, No. 10Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapiesCancer Treatment Reviews, Vol. 29, No. 4EPO-producing gastric carcinoma in a hemodialysis patientAmerican Journal of Kidney Diseases, Vol. 42, No. 1Regulation of angiogenesis by hypoxia: role of the HIF systemNature Medicine, Vol. 9, No. 6Cobalt Inhibits the Interaction between Hypoxia-inducible Factor-α and von Hippel-Lindau Protein by Direct Binding to Hypoxia-inducible Factor-α26 February 2003 | Journal of Biological Chemistry, Vol. 278, No. 18Hypoxia-induced megaloblastosis in vitamin B12-deficient rats1 August 2008 | British Journal of Nutrition, Vol. 89, No. 04Effects of erythropoietin and pentoxifylline on the oxidant and antioxidant systems in the experimental short bowel syndrome7 October 2002 | Cell Biochemistry and Function, Vol. 21, No. 1Optimization of human erythropoietin secretion from MLV-infected human primary fibroblasts used for encapsulated cell therapy3 February 2003 | The Journal of Gene Medicine, Vol. 5, No. 3Oxygen-dependent regulation of hypoxia-inducible factors by prolyl and asparaginyl hydroxylation10 September 2003 | European Journal of Biochemistry, Vol. 270, No. 5Autocrine stimulation by erythropoietin in transgenic mice results in erythroid proliferation without neoplastic transformation☆☆Supported in part by National Institutes of Health Grants KO8 HL02966 (A.M.) and R29 DK44956 (P.T.C.) and by a Medical Research Foundation of Oregon grant (P.T.C.).Blood Cells, Molecules, and Diseases, Vol. 30, No. 1Expression of erythropoietin and erythropoietin receptor in peritoneal endometriosisHuman Reproduction, Vol. 18, No. 1Erythropoietin for critically ill children *Pediatric Critical Care Medicine, Vol. 4, No. 1Red blood cellsThe International Journal of Biochemistry & Cell Biology, Vol. 34, No. 12Angiogenesis and Plasticity: Role of Erythropoietin in Vascular SystemsJournal of Hematotherapy & Stem Cell Research, Vol. 11, No. 6Transfusion-sparing hemostatic agentsCurrent Opinion in Hematology, Vol. 9, No. 6VEGF and the quest for tumour angiogenesis factorsNature Reviews Cancer, Vol. 2, No. 10Negative regulation of exocytosis at the nerve terminal30 July 2002 | Molecular Psychiatry, Vol. 7, No. 6Determinants of erythropoietin release in response to short-term hypobaric hypoxiaRi-Li Ge, S. 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Dorrington, Patrick H. Maxwell, and Peter A. Robbins1 August 2000 | Journal of Applied Physiology, Vol. 89, No. 2The oviduct produces erythropoietin in an estrogen- and oxygen-dependent mannerSeiji Masuda, Toshihiro Kobayashi, Mariko Chikuma, Masaya Nagao, and Ryuzo Sasaki1 June 2000 | American Journal of Physiology-Endocrinology and Metabolism, Vol. 278, No. 6Gender differentiation of the chemoreflex during growth at high altitude: functional and neurochemical studiesV. Joseph, J. Soliz, J. Pequignot, B. Semporé, J. M. Cottet-Emard, Y. Dalmaz, R. Favier, H. Spielvogel, and J. M. Pequignot1 April 2000 | American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 278, No. 4Adaptive responses during anemia and its correction in lambsJohn A. Widness, Lance S. Lowe, Edward F. Bell, Leon F. Burmeister, Donald M. Mock, James A. 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