Produção Nacional
Revisado por pares
Effects of ethanol consumption and alcohol detoxification on the biomechanics and morphology the bone in rat femurs
2015; Instituto Internacional de Ecologia (Brazil); Volume: 75; Issue: 4 Linguagem: Inglês
10.1590/1519-6984.04814
ISSN1678-4375
AutoresJosé Antônio Dias Garcia, André Luiz Thomaz de Souza, Luciana Hoffert Castro Cruz, Petrus Pires Marques, José Ângelo Camilli, Wilson Romero Nakagaki, Alessandra Esteves, W. C. Rossi-Junior, Geraldo José Medeiros Fernandes, Flávia Da Ré Guerra, Evelise Aline Soares,
Tópico(s)Orthopaedic implants and arthroplasty
ResumoThe objective of this study was to verify the effects of ethanol consumption and alcohol detoxification on the biomechanics, area and thickness of cortical and trabecular bone in rat femur. This was an experimental study in which 18 male Wistar rats were used, with 40 days of age, weighing 179 ± 2.5 g. The rats were divided into three groups (n=06): CT (control), AC (chronic alcoholic), DT (detoxification). After experimental procedures, the animals were euthanized by an overdose of the anesthetic and their femurs were collected for mechanical testing and histological processing. All animals did not present malnutrition or dehydration during experimentation period. Morphometric analysis of cortical and trabecular bones in rat femurs demonstrated that AC animals showed inferior dimensions and alcohol detoxification (DT) allowed an enhancement in area and thickness of cortical and trabecular bone. Material and structural properties data of AC group highlighted the harmful effects of ethanol on bone mechanical properties. The results of this study demonstrated that chronic alcoholic rats (AC) presented major bone damage in all analyzed variables. Those findings suggested that alcohol detoxification is highly suggested in pre-operative planning and this corroborates to the success of bone surgery and bone tissue repair. Thanks to the financial support offered by PROBIC - UNIFENAS.
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