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Failure of Cytarabine in Progressive Multifocal Leukoencephalopathy Associated with Human Immunodeficiency Virus Infection

1998; Massachusetts Medical Society; Volume: 338; Issue: 19 Linguagem: Inglês

10.1056/nejm199805073381903

1533-4406

Colin D. Hall, Urania Dafni, David M. Simpson, David B. Clifford, Patricia E. Wetherill, Bruce A. Cohen, Justin McArthur, Harry Hollander, Constantin Yainnoutsos, Eugene O. Major, Linda Millar, Joseph Timpone,

Cooperative Communication and Network Coding

Progressive multifocal leukoencephalopathy affects about 4 percent of patients with the acquired immunodeficiency syndrome (AIDS), and survival after the diagnosis of leukoencephalopathy averages only about three months. There have been anecdotal reports of improvement but no controlled trials of therapy with antiretroviral treatment plus intravenous or intrathecal cytarabine.