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The Practical Application of Three Validated In Vitro Embryotoxicity Tests

2006; SAGE Publishing; Volume: 34; Issue: 5 Linguagem: Inglês

10.1177/026119290603400504

2632-3559

Horst Spielmann, A. Seiler, Susanne Bremer, Lars Hareng, Thomas Härtung, H J Ahr, Elaine M. Faustman, Ulla Haas, Graeme J. Moffat, Heinz Nau, Philippe Vanparys, Aldert H. Piersma, Juan Riego Sintes, Jane Stuart,

Carcinogens and Genotoxicity Assessment

The major limitations of the validated in vitro embryotoxicity tests identified at the 2003 workshop were immediately taken into account by ECVAM in a proposal for an Integrated Project in the EU 6th Framework Programme, entitled ReProTect (22). Since 2004, a consortium of more than 36 laboratories involved in this project have been evaluating existing and newly developed in vitro models for reproductive processes and their integration into a testing strategy. This strategy should provide detailed information on the hazard potentials of chemicals to the mammalian reproductive cycle