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Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

2016; American Association for the Advancement of Science; Volume: 352; Issue: 6284 Linguagem: Inglês

10.1126/science.aaf0659

1095-9203

Patrick Robison, Matthew A. Caporizzo, Hossein Ahmadzadeh, Alexey Bogush, Yingxian Chen, Kenneth B. Margulies, Vivek B. Shenoy, Benjamin L. Prosser,

Microtubule and mitosis dynamics

A close-up view of cardiac cell mechanics Heart cells contain a very well-organized array of cytoskeletal elements, including actin and microtubules that help them to perform their mechanical functions. Robison et al. used an advanced imaging approach to study the inner workings of mouse cardiac myocytes in real time. They observed microtubule “buckling” under contractile force in beating cardiomyocytes. This buckling was regulated by interaction with desmin and by the tubulin tyrosination state. The findings suggest a role for stable detyrosinated microtubules whose buckling under tension contributes to cardiac muscle strength. Science , this issue p. 10.1126/science.aaf0659