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Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

2018; American Association for the Advancement of Science; Volume: 359; Issue: 6376 Linguagem: Inglês

10.1126/science.aad6469

1095-9203

Michael J. Gandal, Jillian R. Haney, Neelroop Parikshak, Virpi Leppä, Gokul Ramaswami, Christopher Hartl, Andrew J. Schork, Vivek Appadurai, Alfonso Buil, Thomas Werge, Chunyu Liu, Kevin P. White, Steve Horvath, Daniel H. Geschwind, Nenad Šestan, Flora M. Vaccarino, Mark Gerstein, Sherman M. Weissman, Sirisha Pochareddy, Matthew W. State, James A. Knowles, Peggy Farnham, Schahram Akbarian, Dalila Pinto, Harm Van Baekl, Stella Dracheva, Andrew E. Jaffe, Thomas M. Hyde, Peter P. Zandi, Gregory E. Crawford, Pat Sullivan, Wesley K. Thompson, Preben Bo Mortensen, Esben Agerbo, Marianne Giørtz Pedersen, Carsten Bøcker Pedersen, Ole Mors, Anders D. Børglum, Merete Nordentoft, David M. Hougaard, Jonas Bybjerg‐Grauholm, Marie Bækvad‐Hansen, Alicia R. Martin, Ashley Dumont, Christine Stevens, Tracy Air, Daniel P. Howrigan, Duncan S. Palmer, Elise Robinson, Kyle F. Satterstrom, Felecia Cerrato, Hailiang Huang, Jacqueline I. Goldstein, Jennifer L. Moran, Joanna Martin Julian, M. Alonge Kimberly, C. Seed Patrick, Patrick Turley, Raymond K. Walters, Rich Belliveau, Stephan Ripke, Timothy Poterba, Mark J. Daly, Benjamin M. Neale, Menachem Fromer, Panos Roussos, Jessica Johnson, Hardik Shah, Milind Mahajan, Eric E. Schadt, Vahram Haroutunian, Douglas M. Ruderfer, Joseph D. Buxbaum, Solveig K. Sieberts, Kristen K. Dang, Ben Logsdon, Lara M. Mangravite, Mette A. Peters, Raquel E. Gur, Chang-Gyu Hahn, Bernie Devlin, Lambertus Klei, David A. Lewis, Barbara K. Lipska, Keisuke Hirai, Hiroyoshi Toyoshiba, Enrico Domenici,

Genomics and Rare Diseases

Genes overlap across psychiatric disease Many genome-wide studies have examined genes associated with a range of neuropsychiatric disorders. However, the degree to which the genetic underpinnings of these diseases differ or overlap is unknown. Gandal et al. performed meta-analyses of transcriptomic studies covering five major psychiatric disorders and compared cases and controls to identify coexpressed gene modules. From this, they found that some psychiatric disorders share global gene expression patterns. This overlap in polygenic traits in neuropsychiatric disorders may allow for better diagnosis and treatment. Science , this issue p. 693