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Abbreviated Regimens of Zidovudine Prophylaxis and Perinatal Transmission of the Human Immunodeficiency Virus

1998; Massachusetts Medical Society; Volume: 339; Issue: 20 Linguagem: Inglês

10.1056/nejm199811123392001

1533-4406

Nancy A. Wade, Guthrie S. Birkhead, Barbara L. Warren, Tina T. Charbonneau, P. Tyler French, Ling Wang, Jeanne B. Baum, James M. Tesoriero, Robert Savicki,

HIV, Drug Use, Sexual Risk

The Pediatric AIDS Clinical Trials Group Protocol 076 reported a reduction in the rate of perinatal transmission of the human immunodeficiency virus (HIV) from 25.5 percent to 8.3 percent with a three-part regimen of zidovudine given ante partum, intra partum, and to the newborn. We examined the effects of abbreviated zidovudine regimens on perinatal HIV transmission using data from the HIV polymerase-chain-reaction (PCR) testing service of the New York State Department of Health. Pregnant women who received abbreviated regimens rather than the recommended regimens did so because of limited prenatal care or by choice.