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12 years of experience with cholecystojejunostomy for the palliative treatment of advanced pancreatic cancer

2016; Elsevier BV; Volume: 18; Linguagem: Inglês

10.1016/j.hpb.2016.02.958

1477-2574

Mariana Barbosa Mazeu de Oliveira, B.D.N. Santos, André de Moricz, Regina Angélica de Araújo Tavares Silva, Adhemar Monteiro Pacheco, Tércio De Campos,

Cholangiocarcinoma and Gallbladder Cancer Studies

Introduction: Pancreatic cancer has a high mortality rate due to Late diagnosis and aggressive behavior. Thus, it becomes essential to understand the forms of palliative treatment. The aims of the study was to evaluate early mortality and reduction of jaundice in patients with pancreatic cancer who underwent cholecystojejunostomy. Method: A retrospectively study analyzing patients who were operated on between 2002 and 2013 was conducted. Patients were categorized according to the resolution of cases: early deaths and late deaths and variables such as bilirubin preoperative and postoperative as well as other liver function tests and organ dysfunction were compared. The Kaplan-Meier and the Cox regression method were used for median overall survival. Results: Most of patients (51,8%) were male. The average age was 62.3 years. Early mortality was 14.5%. Surgical complications were presented in 12.7%. The cholecystojejunostomy was effective in 97% of cases. There was a longer survival in women and patients with serum total preoperative bilirubin less than 15 mg/dL. Conclusions: Cholecystojejunostomy is an effective procedure to relieve obstructive jaundice but not free of complications. Its mortality rate is not insignificant and early mortality is related to the intensity of jaundice.