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Chemical Composition and Antinociceptive Potential of Campomanesia reitziana Fruits

2016; Mary Ann Liebert, Inc.; Volume: 19; Issue: 5 Linguagem: Inglês

10.1089/jmf.2015.0092

1557-7600

Luciane Ângela Nottar Nesello, Adriana Campos, Theodoro Marcel Wagner, Arturo San Feliciano, Fátima de Campos Buzzi, Valdir Cechinel Filho,

Psychedelics and Drug Studies

The methanolic extract from Campomanesia reitziana fruits and the main active principle, identified as 4',6'-dihydroxy-3',5'-dimethyl-2'-methoxy chalcone or dimethyl cardamonin (1), exhibited pronounced antinociceptive effects against two models of pain in mice. Compound 1 caused dose-dependent inhibition of abdominal constrictions, with a calculated ID50 value of 8.1 (6.5-10.1) μmol/kg (i.p.), being about 16-fold more potent than two reference analgesic drugs. Methanolic extract and 1 were also effective against the formalin model, inhibiting both phases of pain, causing reductions of 39.9% and 26.8% (extract, 10 mg/kg) and 52.9% and 57.6% (compound 1, 5 mg/kg) for the first and second phases, respectively.