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Thyroid Diseases after Treatment of Hodgkin's Disease

1991; Massachusetts Medical Society; Volume: 325; Issue: 9 Linguagem: Inglês

10.1056/nejm199108293250902

1533-4406

Steven Hancock, Richard S. Cox, I. Ross McDougall,

Thyroid Cancer Diagnosis and Treatment

Thyroid disease, especially hypothyroidism, is common in patients with Hodgkin's disease who have been treated with irradiation. We reviewed the records of 1787 patients (740 women and 1047 men) with Hodgkin's disease who were treated with radiation therapy alone (810 patients), radiation and chemotherapy (920 patients), or chemotherapy alone (57 patients) at Stanford University between 1961 and 1989. Among these patients, 1533 were alive at the last follow-up, and 254 had died of causes other than Hodgkin's disease. Four other patients were excluded from the analysis because they had undergone thyroidectomy before treatment for Hodgkin's disease. The thyroid was irradiated in 1677 patients. Follow-up averaged 9.9 years.