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Benralizumab: a unique IL-5 inhibitor for severe asthma

2016; Dove Medical Press; Linguagem: Inglês

10.2147/jaa.s78049

1178-6965

Laren Tan, Dorottya Gódor, Jennifer M. Bratt, N.J. Kenyon, Samuel Louie,

Eosinophilic Esophagitis

Abstract: The presence of eosinophilic inflammation is a characteristic feature of chronic and acute inflammation in asthma. An estimated 5%–10% of the 300 million people worldwide who suffer from asthma have a severe form. Patients with eosinophilic airway inflammation represent approximately 40%–60% of this severe asthmatic population. This form of asthma is often uncontrolled, marked by refractoriness to standard therapy, and shows persistent airway eosinophilia despite glucocorticoid therapy. This paper reviews personalized novel therapies, more specifically benralizumab, a humanized anti-IL-5Rα antibody, while also being the first to provide an algorithm for potential candidates who may benefit from anti-IL-5Rα therapy. Keywords: asthma, eosinophils, asthma treatments, benralizumab, IL-5, IL-5Rα, MEDI-563