Leprosy's Footprints in Bone-Marrow Histiocytes
1979; Massachusetts Medical Society; Volume: 300; Issue: 15 Linguagem: Inglês
10.1056/nejm197904123001505
ISSN1533-4406
AutoresChristine Lawrence, Allen J. Schreiber,
Tópico(s)Infectious Diseases and Tuberculosis
ResumoWE recently helped establish the diagnosis of leprosy by finding many Mycobacteria leprae in aspirated bone-marrow histiocytes. Macrophages containing lepra bacilli are found in other tissues,1 , 2 and the bacilli are present in the marrow1 , 3 4 5 in lepromatous leprosy. These striking histiocytes with engulfed bacilli have apparently not previously been described in marrow aspirates.Case ReportsCase 1. A 28-year-old Puerto Rican woman was admitted to the hospital because of papulonodular lesions on her forearms and abdomen. A skin biopsy showed acid-fast bacilli in foamy histiocytes, and lepromatous leprosy was diagnosed. Mild anemia prompted bone-marrow aspiration, which revealed megaloblastic changes, clusters of . . .
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