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[1-8-NαC]-Zanriorb A1, a Proapoptotic Orbitide from Leaves of Zanthoxylum riedelianum

2016; American Chemical Society; Volume: 79; Issue: 5 Linguagem: Inglês

10.1021/acs.jnatprod.5b00177

1520-6025

Pâmela J. dos S. Beirigo, Heron Fernandes Vieira Torquato, Carlos Henrique Corrêa dos Santos, Mário Geraldo de Carvalho, Rosane Nora Castro, Edgar Julian Paredes‐Gamero, Paulo Teixeira de Sousa, Marcos J. Jacinto, Virgínia Cláudia da Silva,

Plant chemical constituents analysis

A new orbitide named [1-8-NαC]-zanriorb A1 (1) was isolated and characterized from the leaves of Zanthoxylum riedelianum using NMR and mass spectrometry. The absolute configuration of the amino acids was determined using Marfey's method on the acid hydrolysates. Compound 1 induced cell death by apoptosis in Jurkat leukemia T cells (IC50 218 nM).