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Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study

2016; Elsevier BV; Volume: 117; Linguagem: Inglês

10.1016/j.biopsycho.2016.04.006

1873-6246

Andrew H. Kemp, Santiago Rodríguez López, Valéria Maria de Azeredo Passos, Márcio Sommer Bittencourt, Eduardo Miranda Dantas, José Geraldo Mill, Antônio Luiz Pinho Ribeiro, Julian F. Thayer, Isabela M. Benseñor, Paulo A. Lotufo,

Blood Pressure and Hypertension Studies

Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N = 8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment.