Portal de Periódicos da CAPES

Species-conserved reconfigurations of brain network topology induced by ketamine

2016; Springer Nature; Volume: 6; Issue: 4 Linguagem: Inglês

10.1038/tp.2016.53

2158-3188

Robert E. Becker, Urs Braun, Adam J. Schwarz, Natalia Gass, Janina I. Schweiger, Wolfgang Weber‐Fahr, Esther Schenker, Michael Spedding, Christian Clemm von Hohenberg, Céline Risterucci, Zhenxiang Zang, O. Grimm, Heike Tost, Alexander Sartorius, Andreas Meyer‐Lindenberg,

Tryptophan and brain disorders

Abstract Species-conserved (intermediate) phenotypes that can be quantified and compared across species offer important advantages for translational research and drug discovery. Here, we investigate the utility of network science methods to assess the pharmacological alterations of the large-scale architecture of brain networks in rats and humans. In a double-blind, placebo-controlled, cross-over study in humans and a placebo-controlled two-group study in rats, we demonstrate that the application of ketamine leads to a topological reconfiguration of large-scale brain networks towards less-integrated and more-segregated information processing in both the species. As these alterations are opposed to those commonly observed in patients suffering from depression, they might indicate systems-level correlates of the antidepressant effect of ketamine.