Portal de Periódicos da CAPES

Deregulation of Rho GTPases in cancer

2016; Taylor & Francis; Volume: 7; Issue: 3 Linguagem: Inglês

10.1080/21541248.2016.1173767

2154-1256

Andrew P. Porter, Alexandra Papaioannou, Angeliki Malliri,

PI3K/AKT/mTOR signaling in cancer

In vitro and in vivo studies and evidence from human tumors have long implicated Rho GTPase signaling in the formation and dissemination of a range of cancers. Recently next generation sequencing has identified direct mutations of Rho GTPases in human cancers. Moreover, the effects of ablating genes encoding Rho GTPases and their regulators in mouse models, or through pharmacological inhibition, strongly suggests that targeting Rho GTPase signaling could constitute an effective treatment. In this review we will explore the various ways in which Rho signaling can be deregulated in human cancers.