Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Myocardial Infarction–Associated Transcript, a Long Noncoding RNA, Is Overexpressed During Dilated Cardiomyopathy Due to Chronic Chagas Disease

2016; Oxford University Press; Volume: 214; Issue: 1 Linguagem: Inglês

10.1093/infdis/jiw095

ISSN

1537-6613

Autores

Amanda Farage Frade, Laurie Laugier, Ludmila Rodrigues Pinto Ferreira, Monique Baron, Luiz Alberto Benvenuti, Priscila Camillo Teixeira, Isabela Cunha Navarro, Sandrine Cabantous, Frederico Moraes Ferreira, Darlan da Silva Cândido, Fábio Antônio Gaiotto, Fernando Bacal, Pablo Maria Alberto Pomerantzeff, Ronaldo Honorato Barros Santos, Jorge Kalil, Edécio Cunha‐Neto, Christophe Chevillard,

Tópico(s)

RNA Research and Splicing

Resumo

Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction–associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.

Referência(s)