Produção Nacional
Revisado por pares
Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8+ T Cells in Lichen Planus
2015; Soc for Publication of Acta Dermato-Venereologica; Volume: 96; Issue: 4 Linguagem: Inglês
10.2340/00015555-2306
ISSN1651-2057
AutoresGabriel Costa de Carvalho, Rosana Domingues, Maurício Lacerda Nogueira, Ana F. Branco, Kelly Cristina Gomes Manfrere, Naiura Vieira Pereira, Valéria Aoki, Mírian Nacagami Sotto, Crislaine Aparecida da Silva, Maria Notomi Sato,
Tópico(s)Chronic Obstructive Pulmonary Disease (COPD) Research
ResumoLichen planus (LP) is a chronic inflammatory mucocutaneous disease. The inflammatory status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation of cytotoxic cells. The aims of this study were to evaluate S100A8 expression in skin lesions and the in vitro effects of S100A8 on CD8+ T cells and natural killer (NK) cells in LP. Increased levels of S100A8/S100A9 were detected in the skin lesions as well as in the sera of subjects with LP. S100A8 expression induced an increased cytotoxic response by peripheral blood CD8+CD107a+ T cells as well as by NK CD56bright cells in patients with LP. Increased expression of interleukin (IL)-1β, tumour necrosis factor (TNF) and IL-6 in the CD8+ T cells of patients with LP was induced by S100A8, in contrast to the control group that produced IL- 10 and interferon (IFN) type I genes. These data suggest that, in individuals with LP, S100A8 may exert distinct immunomodulatory and cytotoxicity functions.
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