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Complete Sequences of mcr-1 -Harboring Plasmids from Extended-Spectrum-β-Lactamase- and Carbapenemase-Producing Enterobacteriaceae

2016; American Society for Microbiology; Volume: 60; Issue: 7 Linguagem: Inglês

10.1128/aac.00550-16

1098-6596

Aiqing Li, Yong Yang, Minhui Miao, Kalyan D. Chavda, José R. Mediavilla, Xiaofang Xie, Ping Feng, Yi‐Wei Tang, Barry N. Kreiswirth, Liang Chen, Hong Du,

Pharmaceutical and Antibiotic Environmental Impacts

ABSTRACT Here we completely sequenced four mcr-1 -haboring plasmids, isolated from two extended-spectrum-β-lactamase (ESBL)-producing Escherichia coli and two carbapenemase-producing Klebsiella pneumoniae clinical isolates. The mcr-1 -harboring plasmids from an E. coli sequence type 2448 (ST2448) isolate and two K. pneumoniae ST25 isolates were identical (all pMCR1-IncX4), belonging to the IncX4 incompatibility group, while the plasmid from an E. coli ST2085 isolate (pMCR1-IncI2) belongs to the IncI2 group. A nearly identical 2.6-kb mcr-1-pap2 element was found to be shared by all mcr-1 -carrying plasmids.