Effect of donepezil and kamikihito combination therapy on cognitive function in A lzheimer's disease: R etrospective study
2016; Wiley; Volume: 3; Issue: 2 Linguagem: Inglês
10.1002/tkm2.1045
ISSN2053-4515
Autores Tópico(s)Cholinesterase and Neurodegenerative Diseases
ResumoABSTRACT Aim Kamikihito ( KKT ) is a herbal drug used in traditional J apanese medicine (kampo medicine) to treat psychological symptoms such as insomnia, restlessness, and fear. The aim of this study was to investigate the effect of the combination of KKT extract and donepezil ( DPZ ) on the cognitive function of patients diagnosed with A lzheimer's disease ( AD ). Methods The effect of this combination therapy ( CBT ) was analyzed retrospectively using M ini‐ M ental S tate E xamination ( MMSE ). AD patients were treated with DPZ (5 mg/day). Those with psychological symptoms, such as insomnia, were also given the KKT extract (7.5 g/day), beginning 3 months after the initiation of DPZ . Results Medical records of patients who visited the outpatient department for the first time between M ay 2010 and J anuary 2013 were retrospectively evaluated, and six patients from each group selected as candidates for this study. Changes in total MMSE score for the DPZ and CBT groups were unremarkable until 6 months; at 12 months the scores were markedly, but non‐significantly, different: cognitive function was maintained in the CBT group while it deteriorated in the DPZ group. On MMSE subscale analysis, delayed memory recall score in the CBT group was sustained in a statistically significant manner. Conclusion CBT may prolong the effect of DPZ and, thus, CBT may be more beneficial than monotherapy using DPZ .
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