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Treatment of Venous Thrombosis with Intravenous Unfractionated Heparin Administered in the Hospital as Compared with Subcutaneous Low-Molecular-Weight Heparin Administered at Home

1996; Massachusetts Medical Society; Volume: 334; Issue: 11 Linguagem: Inglês

10.1056/nejm199603143341102

1533-4406

Maria M.W. Koopman, Paolo Prandoni, Franco Piovella, Paul Ockelford, Desiderius P.M. Brandjes, Jan van der Meer, Alexander Gallus, Gérald Simonneau, Colin Chesterman, Martin H. Prins, Patrick M. Bossuyt, Hanneke de Haes, A.G.M. van den Belt, Luc Sagnard, Pascal d’Azemar, Harry R. Büller,

Blood Coagulation and Thrombosis Mechanisms

An intravenous course of standard (unfractionated) heparin with the dose adjusted to prolong the activated partial-thromboplastin time to a desired length is the standard initial in-hospital treatment for patients with deep-vein thrombosis, but fixed-dose subcutaneous low-molecular-weight heparin appears to be as effective and safe. Because the latter treatment can be given on an outpatient basis, we compared the two treatments in symptomatic outpatients with proximal-vein thrombosis but no signs of pulmonary embolism.