Slippery Liquid‐Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non‐Adherent Pathogens in Surrounding Media: A Controlled Release Approach
2016; Wiley; Volume: 26; Issue: 21 Linguagem: Inglês
10.1002/adfm.201505522
ISSN1616-3028
AutoresUttam Manna, Namrata Raman, Michael A. Welsh, Yashira M. Zayas‐Gonzalez, Helen E. Blackwell, Sean P. Palecek, David M. Lynn,
Tópico(s)Bacterial biofilms and quorum sensing
ResumoMany types of slippery liquid-infused porous surfaces (or 'SLIPS') can resist adhesion and colonization by microorganisms. These 'slippery' materials thus offer new approaches to prevent fouling on a range of commercial and industrial surfaces, including biomedical devices. However, while SLIPS can prevent fouling on surfaces to which they are applied, they can currently do little to prevent the proliferation of non-adherent (planktonic) organisms, stop them from colonizing other surfaces, or prevent them from engaging in other behaviors that could lead to infection and associated burdens. Here, we report an approach to the design of multi-functional SLIPS that addresses these issues and expands the potential utility of slippery surfaces in antimicrobial contexts. Our approach is based on the incorporation and controlled release of small-molecule antimicrobial agents from the porous matrices used to host infused slippery oil phases. We demonstrate that SLIPS fabricated using nanoporous polymer multilayers can prevent short- and longer-term colonization and biofilm formation by four common fungal and bacterial pathogens (
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