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Human Immunodeficiency Virus/Hepatitis C Virus Coinfection in Spain: Prevalence and Patient Characteristics

2016; Oxford University Press; Volume: 3; Issue: 2 Linguagem: Inglês

10.1093/ofid/ofw059

2328-8957

Juan Berenguer, Antonio Rivero, Inmaculada Jarrín, M.J. Núñez, María Jesús Vivancos, Manel Crespo, María Jesús Téllez, Peré Domingo, José Antonio Iribarren, Arturo Artero, Manuel Márquez, Ignacio de los Santos, J. Marta Moreno, Marta Montero, Juan González‐García, Leire Pérez‐Latorre, Pilar Miralles, J. C. Lopez, F Parras, B. Padilla, Teresa Aldámiz, A. Carrero, Cristina Díez, Francisco Tejerina, Juan Berenguer, M.J. Núñez, Francisco Arnalich, José Ramón Arribas, José I. Bernardino, Juan González‐García, Víctor Hontañón, Luz Martín‐Carbonero, Rocío Montejano, Marisa Montes, V. Moreno, Ignacio Valero, Carolina Navarro-San Francisco, M.J. Núñez, Eulalia Valencia, Juan González‐García, Francisca Cuenca, Antonio Rivero, Inmaculada Jarrín, María Jesús Vivancos, Santiago Moreno, Ana Moreno, José L. Casado, María Jesús Pérez‐Elías, Carmen Quereda, Ana Gual-de-Torrella, Jordi Navarro, Natàlia Ramos, Manuel Crespo, M.E. Rodrigo, Vicente Estrada, Jorge Vergas, María Jesús Téllez, J. Muñoz, M Gutiérrez, Gràcia Mateo, Josep M. Guardiola, Peré Domingo, Maialen Ibarguren, M.P. Carmona, Francisco Rodríguez-Arrondo, Má Goenaga, Harkaitz Azkune, M. A. von Wichmann, José Antonio Iribarren, Jorge Carmena, Arturo Artero, Juan Pablo Ruíz, Enrique Nuño, Rosario Palacios, José Ramón Santos, Manuel Márquez, José Sanz, Ignacio de los Santos, J.M. Ramírez-Moreno, Piedad Arazo, Marta Montero, María Tasias, S. Cuéllar, Eva Muñoz, Marino Blanes, Jovita Fernández‐Pinero, José López-Aldeguer, Miguel Salavert, Asunción Hernando, Lourdes Domínguez, Otilia Bisbal, María Lagarde, Mariano Matarranz, Rafael Rubio, Federico Pulido, Coral García, Carlos Armiñanzas, S Echevarrı́a, M. Gutiérrez-Cuadra, Carmen Fariñas, Livia Giner, Sergio Reus, Esperanza Merino, Vicente Boix, Diego Torrús, Idoia Portilla, M. Pampliega, María José Díez, Isabel Egea, Joaquín Portilla, Oscar Luis Ferrero, Santa Magdalena Mercado Ibarra, Iván Méndez-López, Mónica de la Peña, Z Zubero, J. Baraia, J. Muñoz, J. de Miguel, Alberto Arranz, E Casas, José Sanz, Ana Ferrer, Marı́a José Galindo, Luis Garcı́a, L. Pérez, José A. Oteo, M Velasco, Laura Moreno‐Galarraga, Ramona Hervás, Juan Emilio Losa, David Vinuesa, Luis Muñoz, José Hernández‐Quero, Sergio Veloso, Joaquim Peraire, Consuelo Viladés, Montserrat Vargas, Ana María Castellano, Francesc Vidal, Rafael Silvariño, A.J. Orti, Elena Chamarro, Cristina Escrig, Paloma Geijo, Ángel Chocarro, Carmen Rodríguez, Teresa Puerta, Mafalda Raposo, Mar Vera, Jorge del Romero, Josep Bisbe, Carmen Luna, Ramón Teira, Josep Vilaró, Ariadne Vegas, Ariel Cano, Andrea Alcaraz, Álvaro Muñoz, Enrique Bernal, M. Campoamor, M.J. Tuya, Adelina Gimeno, Camilo Montero, Sari Arponen, Luís Force, Pilar Barrufet, G. Gaspar, Gerardo Alonso, Claudio Toledo, G. Lara, I. Fernández, M. C. Esteban,

Hepatitis B Virus Studies

Background. The purpose of this study was to assess the prevalence of anti-hepatitis C virus (HCV) antibodies (Abs) and active HCV infection in human immunodeficiency virus (HIV)-infected (HIV+) patients in Spain in 2015. This was a cross-sectional study. Methods. The study was performed in 41 centers in 2015. Sample size was estimated for an accuracy of 2%, the number of patients from each hospital was determined by proportional allocation, and patients were selected using simple random sampling. Results. The reference population was 35 791 patients, and the sample size was 1867 patients. Hepatitis C virus serostatus was known in 1843 patients (98.7%). Hepatitis C virus-Abs were detected in 695 patients (37.7%), in whom the main route of HIV acquisition was injection drug use (75.4%). Of these 695 patients, 402 had HCV RNA, 170 had had a sustained viral response (SVR) after anti-HCV therapy, and 102 cleared HCV spontaneously. Hepatitis C virus-ribonucleic acid results were unknown in 21 cases. Genotype distribution (known in 367 patients) was 1a in 143 patients (39.0%), 4 in 90 (24.5%) patients, 1b in 69 (18.8%) patients, 3 in 57 (15.5%) patients, 2 in 5 (1.4%) patients, and mixed in 3 (0.8%) patients. Liver cirrhosis was present in 93 patients (23.1%) with active HCV infection and in 39 (22.9%) patients with SVR after anti-HCV therapy. Conclusions. The prevalence of HCV-Abs and active HCV infection in HIV+ patients in Spain is 37.7% and 22.1%, respectively; these figures are significantly lower than those recorded in 2002 and 2009. The predominant genotypes in patients with active HCV infection were 1a and 4. A high percentage of patients had cirrhosis. Cirrhosis is also common in patients with SVR after anti-HCV therapy.