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Progress report on chlorambucil therapy in postsplenectomy patients with progressive hairy cell leukemia

1981; Elsevier BV; Volume: 57; Issue: 3 Linguagem: Inglês

10.1182/blood.v57.3.464.bloodjournal573464

1528-0020

HM Golomb,

Immune Cell Function and Interaction

Of eight patients with progressive hairy cell leukemia who were treated with daily doses of an alkylating agent (chlorambucil, 4 mg) for at least 6 mo, seven have had an objective response, as measured by improved blood counts. Two patients were pancytopenic and had almost total bone marrow replacement with hairy cells at the initiation of chemotherapy; approximatley 6 mo later, their blood counts and bone marrow had improved dramatically. The five other patients had the leukemic form of the disease, and all responded to therapy. It is important to identify postsplenectomy patients with progressive disease in order to initiate low-dose single-agent chemotherapy.