Development of a commercial scale process for production of 1,4-butanediol from sugar
2016; Elsevier BV; Volume: 42; Linguagem: Inglês
10.1016/j.copbio.2016.04.016
ISSN1879-0429
AutoresAnthony P. Burgard, Mark J. Burk, Robin Osterhout, Stephen Van Dien, Harry Yim,
Tópico(s)Enzyme Catalysis and Immobilization
ResumoA sustainable bioprocess for the production of 1,4-butanediol (BDO) from carbohydrate feedstocks was developed. BDO is a chemical intermediate that goes into a variety of products including automotive parts, electronics, and apparel, and is currently manufactured commercially through energy-intensive petrochemical processes using fossil raw materials. This review highlights the development of an Escherichia coli strain and an overall process that successfully performed at commercial scale for direct production of bio-BDO from dextrose. Achieving such high level performance required an integrated technology platform enabling detailed engineering of enzyme, pathway, metabolic network, and organism, as well as development of effective fermentation and downstream recovery processes.
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