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Comparison of Phacotrabeculectomy With 5-Fluorouracil, Mitomycin-C, and Without Antifibrotic Agents

1999; Volume: 30; Issue: 5 Linguagem: Inglês

10.3928/1542-8877-19990501-08

2325-8179

Donald L. Budenz, M.F. Pyfer, Kuldev Singh, Jeffrey A. Gordon, Jody R. Piltz‐Seymour, Edwin U. Keates,

Ocular Infections and Treatments

* BACKGROUND AND OBJECTIVE: To evaluate the potential benefits, complications, and prognostic risk factors for failure of phacotrabeculectomy performed with or without 5-fluorouracil (5-FU) and mitomycin-C (MMC). * PATIENTS AND METHODS: Retrospective chart review of 78 patients who underwent phacotrabeculectomy during a 2-year period. Patients were divided into 3 groups, those who received 5-FU (N=28), MMC (N=29), or no antifibrotic agent (N=21). * RESULTS: All 3 groups had statistically significant lower intraocular pressures (IOP) on fewer antiglaucomatous medications at 6-month, 12-month, and last follow-up compared to preoperative levels (P<.05). Intraocular pressures were lower in the group that received MMC compared to the 5-FU group, but not in the group that did not receive antimetabolites, at all time intervals measured (P<.05). Black race was a strong predictor of failure of trabeculectomy (P=009). No differences in final visual acuity or complications were found between groups. * CONCLUSIONS: Phacotrabeculectomy is effective regardless of antimetabolite use. Race is a strong predictor of failure. [Ophthalmic Surg Lasers 1999;30:367-374.]