25I-NBOMe: The legal LSD
2016; Cambridge University Press; Volume: 33; Issue: S1 Linguagem: Inglês
10.1016/j.eurpsy.2016.01.006
ISSN1778-3585
AutoresI. Ezquiaga, M. Grifell, Liliana Galindo, Leticia Martínez, Á. Palma, P. Quintana, Mireia Ventura, Enriqueta Pujol‐Ribera, Lynette M. Pujol, I. Fornís, Marta Torrens, Magı́ Farré,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoIntroduction Novel psychoactive substances (NPS) use is progressively increasing year on year. A new group of phenethylamines sold as legal stimulants and hallucinogens is being reported increasingly since 2012. Within this group, 25I-NBOMe is an outstanding substance with powerful effects and high affinity with the serotonin 2a (5HT2a) receptor. Several toxicity cases have been reported so far. Objectives To describe the presence of 25I-NBOMe and its characteristics in samples delivered to Energy Control from 2009 to 2015 in Spain. Methods Among the samples, 21,198 analyzed from august 2009 to august 2015 and only those samples containing 25I-NBOMe were studied ( n = 56). Samples were analyzed by Energy Control, a Spanish harm-reduction NGO that offers users the possibility of analyzing the substances they intend to consume. Analysis was done by Gas Chromatography–Mass Spectrometry. Results From 56 samples were 25I-NBOMe was found, 24 were bought as LSD (42.8%), 12 as 25I-NBOMe (21.4%), 4 as 25C-NBOMe (7.1%), 4 as 25I-NBOH (7.1%) and 12 as other substances (21.4%), gummy bears included. All samples were received from 2012 on, having the highest peak on 2013 (19 samples). Conclusions 25I-NBOMe consumption represents an emerging issue with potential harmful effects, especially when the substance used is not the expected. Further pharmacokinetic, pharmacodynamic, clinical and epidemiological researches should be conducted to deepen knowledge about 25I-NBOMe and the management of its possible toxic effects. Physicians should be aware of NPS, their increasing use and the clinical differences between them. Disclosure of interest The authors have not supplied their declaration of competing interest.
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