‘Big Data’ in Pharmaceutical Science: Challenges and Opportunities
2014; Future Science Ltd; Volume: 6; Issue: 8 Linguagem: Inglês
10.4155/fmc.14.45
ISSN1756-8927
AutoresAl G. Dossetter, Gerhard F. Ecker, Hugh Laverty, John P. Overington,
Tópico(s)Bioinformatics and Genomic Networks
ResumoFuture Medicinal ChemistryVol. 6, No. 8 Ask the Experts'Big data' in pharmaceutical science: challenges and opportunitiesPublished Online:25 Jun 2014https://doi.org/10.4155/fmc.14.45AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleAbstractFuture Medicinal Chemistry invited a selection of experts to express their views on the current impact of big data in drug discovery and design, as well as speculate on future developments in the field. The topics discussed include the challenges of implementing big data technologies, maintaining the quality and privacy of data sets, and how the industry will need to adapt to welcome the big data era. Their enlightening responses provide a snapshot of the many and varied contributions being made by big data to the advancement of pharmaceutical science.References1 Open PHACTS. www.openphacts.orgGoogle Scholar2 SALT knowledge sharing. www.medchemica.com/salt.htmlGoogle Scholar3 Dossetter AG, Griffen EG, Leach AG. Matched molecular pair analysis in drug discovery. Drug Discov. Today 18(15–16), 724–731 (2013).Crossref, Medline, CAS, Google Scholar4 Griffen E, Leach AG, Robb GR, Warner DJJ. Matched molecular pairs as a medicinal chemistry tool. J. Med. Chem. 54, 7739–7750 (2011).Crossref, Medline, CAS, Google Scholar5 Session 3 (R&D): industry perspective on PPPs and the link between new business models and the regulatory framework. www.ema.europa.eu/docs/en_GB/document_library/Presentation/2013/11/WC500154182.pdfGoogle Scholar6 eTriks. www.etriks.orgGoogle Scholar7 European Medical Information Framework. www.imi.europa.eu/content/emifGoogle Scholar8 EHR4CR: electronic health records for clinical research. www.ehr4cr.euGoogle Scholar9 Pharmacokinetic–pharmacodynamic modeling platform 2.0. www.tipharma.com/pharmaceutical-research-projects/silico-modeling/pk-pd-modeling-platform-2.html Google Scholar10 US cross-country skier Kris Freeman named to 2014 Olympic team. https://investor.lilly.com/releasedetail.cfm?releaseid=820578Google ScholarFiguresReferencesRelatedDetailsCited ByOptimization of the lyophilisation process for esomeprazole 40 mg powder for solution for injection/infusion using quality by design conceptJournal of Drug Delivery Science and Technology, Vol. 70Recent Development of Optimization of Lyophilization ProcessJournal of Chemistry, Vol. 2019SAR Matrix Method for Large-Scale Analysis of Compound Structure–Activity Relationships and Exploration of Multitarget Activity Spaces18 October 2018De-orphaning the marine natural product (±)-marinopyrrole A by computational target prediction and biochemical validation1 January 2017 | Chemical Communications, Vol. 53, No. 14Sparse Neural Network Models of Antimicrobial Peptide-Activity Relationships11 July 2016 | Molecular Informatics, Vol. 35, No. 11-12Cheminformatics Research at the Unilever Centre for Molecular Science Informatics Cambridge10 March 2015 | Molecular Informatics, Vol. 34, No. 9Big Data Literature SearchBig Data, Vol. 2, No. 4 Vol. 6, No. 8 Follow us on social media for the latest updates Metrics Downloaded 288 times History Published online 25 June 2014 Published in print May 2014 Information© Future Science LtdDisclaimerThe opinions expressed in this interview are those of the interviewee and do not necessarily reflect the views of Future Science Ltd.Financial & competing interests disclosureH Laverty works for the Innovative Medicines Initiative. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.No writing assistance was utilized in the production of this manuscript.PDF download
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