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Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients

2016; Cell Press; Volume: 29; Issue: 5 Linguagem: Inglês

10.1016/j.ccell.2016.04.001

1878-3686

Yuan Yuan, Lingxiang Liu, Hu Chen, Yumeng Wang, Yanxun Xu, Huzhang Mao, Jun Li, Gordon B. Mills, Yongqian Shu, Liang Li, Han Liang,

Bioinformatics and Genomic Networks

An individual's sex has been long recognized as a key factor affecting cancer incidence, prognosis, and treatment responses. However, the molecular basis for sex disparities in cancer remains poorly understood. We performed a comprehensive analysis of molecular differences between male and female patients in 13 cancer types of The Cancer Genome Atlas and revealed two sex-effect groups associated with distinct incidence and mortality profiles. One group contains a small number of sex-affected genes, whereas the other shows much more extensive sex-biased molecular signatures. Importantly, 53% of clinically actionable genes (60/114) show sex-biased signatures. Our study provides a systematic molecular-level understanding of sex effects in diverse cancers and suggests a pressing need to develop sex-specific therapeutic strategies in certain cancer types.