Alkene Synthesis
1991; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-08-052349-1.00020-2
Autores Tópico(s)Asymmetric Synthesis and Catalysis
ResumoIn this chapter, the various methods of converting a carbonyl derivative to an alkene are discussed. Particular focus has been given to recently developed methods and their use in the context of natural product synthesis. Formally this volume in the series is devoted to nonstabilized carbanion additions, but this mechanistic definition has not been strictly adhered to in this chapter. The methods are categorized according to the type of alkene synthesized, and the stabilizing group attached to the anion or carbene. In addition, all of the methods discussed involve the addition of a carbon unit to the carbonyl, followed by some type of elimination or cleavage to the alkene. To further narrow the scope of this chapter, the added carbon unit and the original carbonyl carbon must form the units of the alkene, as shown in Scheme 1. Aldehydes, ketones, esters and lactones, and amides and lactams are all featured in these sections, depending on the synthetic method being discussed.
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