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The Transport of Endogenous Vitamin B12 in Normal Human Serum

1976; Portland Press; Volume: 51; Issue: 1 Linguagem: Inglês

10.1042/cs0510047

0301-0538

J. M. England, M. C. Down, Irene J. Wise, J. C. Linnell,

Porphyrin Metabolism and Disorders

1. Serum from normal subjects has been chromatographed on Sephadex G-200 columns and the fractions containing transcobalamins 0, I and II have been identified. 2. The fractions corresponding to transcobalamin I contained, on average, 90% of the endogenous vitamin B12. Only 3% was attached to transcobalamin 0, and 7% was bound to transcobalamin II.